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Project title: Interdisciplinary Frontier Hub for Enhancing Planetary Resilience through Low-Temperature Plasma Science and Genetics
Human survival is increasingly threatened by the limits of the planetary boundaries. To address these challenges and enhance the sustainability of agriculture, forestry, and fisheries, this project aims to strengthen planetary resilience by leveraging low-temperature plasma technologies to regulate epigenetics—without relying on fossil fuels. Instead, it utilizes atmospheric resources, water, and renewable energy.
The initiative will establish a cross-disciplinary research network that integrates plasma science and genetics, creating a new academic domain that bridges these fields. This hub will contribute to food security and global sustainability by pioneering innovative approaches to biological control and environmental adaptation.
Terminology– What is Epigenetics?: 🧬 Epigenetics refers to the study of changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be triggered by environmental factors, chemical signals, or physical stimuli, and they influence how genes are turned on or off. In agriculture and life sciences, epigenetic regulation is a promising tool for enhancing stress resistance, improving crop traits, and adapting organisms to changing environments—all without genetic modification.
事業名：地球レジリエンス強化に向けた低温プラズマ学と遺伝学のフロンティア学際ハブ
概要： 人類の生存は、プラネタリーバウンダリー（地球の限界）によれば、ますます脅かされています。これらの課題に対応し、農林水産業の持続可能性を高めるため、本事業では化石燃料に依存せず、大気・水・再生可能エネルギーを活用し、低温プラズマ技術によるエピジェネティクス制御を通じて、地球レジリエンスの強化を目指します。
この取り組みでは、低温プラズマ学と遺伝学を融合させた新たな学術領域の創成を目指し、異分野融合型の研究ネットワークを構築します。食料安全保障や国際的課題への対応に貢献する革新的な生物制御技術や環境適応技術の開発を推進します。
実施期間： 2025年度より2034年度
用語解説： 🔬 エピジェネティクス（Epigenetics） とは、DNAの塩基配列そのものを変えることなく、遺伝子の働き方（発現）を制御する仕組みを指します。環境要因や化学的刺激によって、遺伝子のオン・オフが調整されることで、生物の性質や反応が変化します。農業や医療分野では、エピジェネティクスを活用することで、作物の耐性強化や病気の予防などに応用が期待されています。
Plasma-assisted material processing (Go to publication (link)). Plasma process hierarchy comprises heterogeneous phases of plasma, sheath, and surface (Link to Fig), Mechanisms behind the cyclic atomic layer etching processes (Link to Fig.)
Project area name is "Plasma-driven seed memory operation: Frontiers in molecular dynamics in seeds driven by plasma"
24H02254 "プラズマ駆動生化学反応の学理構築：活性種の動態解析" (KAKEN) Principal investigator: Kenji Ishikawa
Functional nitrogen science is now emerged for effective utilization of reactive nitrogen species (RNS). The technologies are related to water and air plasma-based nitrogen fixation. Electron impact reactions and chemical reactions among nitrogen, oxygen, and hydrogen, can occur on non-equilibrium plasma processing. Key issues are on in situ generation of RNS at the point of use and plasma-based nitrogen cycles of ammonia and nitric acid. (link to) Ishikawa Jpn. J. Appl. Phys. 61 SA0802 (2022).
Nitrogen derivatives (Diagram): Short-lived nitrogen derivatives react to generate various RNS in situ through oxidation and hydrogenation.
Color: Oversea, Domestic
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The plasma-activated lactated solution (PAL) exhibits antitumor effects in glioblastoma U251SP cells. The PAL-treated U251SP cells exhibited changes in intracellular metabolites that were reductive in the redox state.
Kenji Ishikawa, Yugo Hosoi et al. Archives of Biochemistry and Biophysics 688, 108414 (pp. 1-9) (July 30, 2020). link
Naoyoyuki Kurake, Kenji Ishikawa et al. Archives of Biochemistry and Biophysics 662, pp.83-92 (February 15, 2019). link
Our paper was published on-line in the Applied Physics Letters (IF 2011 = 3.844) on July 2 issue of 2012.
Kenji Ishikawa et al. Appl. Phys. Lett. 101, 013704 (2012). link, arXiv
Our paper was published in the Journal of Physical Chemistry Letters (I.F. 2011 = 6.213)
We report on the surface modification of polytetrafluoroethylene (PTFE) as an example of soft- and bio-materials that occur under plasma discharge by kinetics analysis of radical formation using in situ real-time electron spin resonance (ESR) measurements. During irradiation with hydrogen plasma, simultaneous measurements of the gas-phase ESR signals of atomic hydrogen and the carbon dangling bond (C-DB) on PTFE were performed. Dynamic changes of the C-DB density were observed in real time, where the rate of density change was accelerated during initial irradiation and then became constant over time. It is noteworthy that C-DBs were formed synergistically by irradiation with both vacuum ultraviolet (VUV) and atomic hydrogen. The in situ real-time ESR technique is useful to elucidate synergistic roles during plasma surface modification.
Kenji Ishikawa et al. J. Phys. Chem. Lett. 2, 1278 (2011). link
This paper won the 11th Plasma Electronics Award awarded by the Plasma Electronics division of the Japanese Society of Applied Physics on March 28, 2013.
